Mitochondrial Approaches for Neuroprotection
نویسندگان
چکیده
منابع مشابه
Mitochondrial approaches for neuroprotection.
A large body of evidence from postmortem brain tissue and genetic analysis in humans and biochemical and pathological studies in animal models (transgenic and toxin) of neurodegeneration suggest that mitochondrial dysfunction is a common pathological mechanism. Mitochondrial dysfunction from oxidative stress, mitochondrial DNA deletions, pathological mutations, altered mitochondrial morphology,...
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Mitochondrial dysfunction contributes to the pathophysiology of acute neurologic disorders and neurodegenerative diseases. Bioenergetic failure is the primary cause of acute neuronal necrosis, and involves excitotoxicity-associated mitochondrial Ca(2+) overload, resulting in opening of the inner membrane permeability transition pore and inhibition of oxidative phosphorylation. Mitochondrial ene...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2008
ISSN: 0077-8923
DOI: 10.1196/annals.1427.027